EPB41L2 Antibody

Code CSB-PA000768
Size US$100
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  • Western Blot analysis of K562 cells using 4.1G Polyclonal Antibody
  • Western Blot analysis of K562 cells using 4.1G Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
EPB41L2
Alternative Names
4.1 G antibody; 4.1G antibody; AW555191 antibody; Band 4.1 like protein 2 antibody; Band 4.1-like protein 2 antibody; D10Ertd398e antibody; DKFZp781D1972 antibody; DKFZp781H1755 antibody; E41L2_HUMAN antibody; Epb41l2 antibody; Erythrocyte membrane protein band 4.1 like 2 antibody; Erythrocyte membrane protein band 4.1 like protein 2 antibody; Generally expressed protein 4.1 antibody; NBL2 antibody; OTTHUMP00000017197 antibody; OTTHUMP00000040262 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human 4.1G.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
Gene References into Functions
  1. Ca(2+)/CaM binding to GHP, and more specifically to pepG, has profound effects on other functional domains of 4.1G PMID: 23354586
  2. 4.1G protein depresses PTH-related protein receptor-mediated Gs signaling pathway by suppression of adenylyl cyclase-mediated cAMP production. PMID: 23201780
  3. A phosphoserine-dependent tethering role for protein 4.1G in lipid rafts provides insight into the unique phosphoserine-based regulation of FcgammaRI receptor signaling. PMID: 22003208
  4. PTA-1(CD226 antigen) is localized to membrane rafts and binds the carboxyl-terminal domain of isoforms of the actin-binding protein 4.1G and also can bind human discs large providing the structural basis for a regulated molecular adhesive complex PMID: 15138281
  5. An alternatively spliced 4.1G product is shown to be associated with increased Fc gamma RI binding in yeast two-hybrid assays, and to be selectively enriched in most immune cells at the transcript level. PMID: 18023480

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Subcellular Location
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cell membrane.
Tissue Specificity
Widely expressed.
Database Links

HGNC: 3379

OMIM: 603237

KEGG: hsa:2037

STRING: 9606.ENSP00000338481

UniGene: Hs.486470

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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