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Coronaviruses have four structural proteins (E,M,N,S protein) that can bind to membrane receptors on host cells, thereby mediating the fusion of the virus and the cell membrane. After the S protein of SARS-CoV-2 interacts with ACE2 and then enters the cell through endocytosis, Cathepsin B/L degrades the Spike protein to release nucleic acids of virus. In addition, CD147 also plays a functional role in promoting SARS-CoV-2 invasion into host cells.
Recombinant Human ACE2 Protein (His Tag)
Recombinant Human Cathepsin B/CTSB Protein (His Tag)
Recombinant Mouse Cathepsin B/CTSB Protein (His Tag)
Recombinant Human Cathepsin L/CTSL Protein (His Tag)
Recombinant Mouse Cathepsin L/CTSL Protein (aa 18-334, His Tag)
Recombinant Human CD147/Basigin Protein (His Tag)
Recombinant Mouse CD147/Basigin Protein (aa 22-325, His Tag)
Accumulating research evidence indicates that many patients with severe COVID-19 might have a cytokine storm syndrome and this suggests that people with severe COVID-19 or suspicious COVID-19 infection should be monitored for hyperin flammation.
Since the SARS-CoV2-Spike protein and Nucleocapsid Protein (NP) are the biomarkers of 2019-nCoV, and angiotensin convertenzyme2 (ACE-2) is the main surface receptor to SARS-CoV2 , it is important to fully understand the role these proteins play in SARS-CoV-2 infection. Elabsicnece® offers a variety of antibodies to investigate the mechanisms of the SARS-CoV-2 life cycle.
SARS-COV-2 Spike Monoclonal Antibody(2019-nCoV)
SARS-COV-2 Spike S1 Monoclonal Antibody(2019-nCoV)
SARS-COV-2 Spike RBD Polyoclonal Antibody(2019-nCoV)
SARS-COV-2 NP Monoclonal Antibody(2019-nCoV)
SARS-COV-2 NP ScFv Monoclonal Antibody(2019-nCoV)
ACE2 Polyclonal Antibody
In vitro experiments using cell lines for drug screening can greatly improve the speed of screening anti-SARS-CoV-2 drugs.
VERO C1008 [Vero E6] cell line
Vero Cell Line
CV-1 [Part of the Wistar Special Collection] Cell Line
Calu-3 Cell Line
A549 [A-549] Cell Line
HuH-7 Cell Line
Caco-2 Cell Line
Mv.1.Lu [NBL-7; Mv1Lu] Cell Line
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