General
Numer kat.	bs-1016R
Opis produktu:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic mannerin connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanismsregulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. [FUNCTION] E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. [SUBUNIT] Homodimer; disulfide-linked. Interacts directly, via the cytoplasmic domain, with CTNNB1 or JUP to form the PSEN1/cadherin/catenin adhesion complex which connects to the actin skeleton through the actin binding of alpha-catenin. Interaction with PSEN1, cleaves CDH1 resulting in the disassociation of cadherin-based adherens junctions (CAJs). Interacts with AJAP1, CTNND1 and DLG7. [SUBCELLULAR LOCATION] Cell junction. Cell membrane; Single-pass type I membrane protein.
Product Size
Ilość w opakowaniu	100ug Lyophilized
Producent	Bioss